Gene: [04^/PGM2] phosphoglucomutase 2;


COM

 Until 1984 the enzyme code was EC:2.7.5.1.

FUN

 [1] Systematic name: alpha-D-glucose 1,6-phosphomutase. Catalyzes reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
[2] Maximum activity is only obtained in the presence of alpha-D-glucose 1,6-bisphosphate. This bisphosphate is an intermediate in the reaction, being produced by transfer of a phosphate residue from the enzyme to the substrate, but the dissociation of bisphosphate from the enzyme complex is much slower than the overall isomerization. Also, more slowly, catalyses the interconversion of 1-phosphate and 6-phosphate isomers of many other alpha-D-hexoses, and the interconversion of alpha-D-ribose 1-phosphate and 5-phosphate."

TIS

 The enzyme is predominantly expressed in red blood cells.

FAG

 On the locations of genes coding for phosphoglucomutase isoforms, see GEM:01p31/PGM1."

REF

 LOC,CYG,LIN "Bocian &: CCG, 25, (HGM5), 138, 1979
LOC,CYG,LIN "Francke U, Brown: CCG, 22, (HGM4), 401-405, 1978
FUN,PEP,FOG "Hopkinson, Harris: Ann Hum Genet, 30, 167-181, 1966
FUN,PEP,FOG "Hopkinson, Harris: Nature, 208, 410-412, 1965
LOC,CYG,LIN "McAlpine PJ &: CCG, 14, (HGM2), 368-369, 1975
FUN,PEP,FOG "Parrington &: Ann Hum Genet, 32, 27-34, 1968
LOC,CYG,LIN "Sparkes RS &: CCG, 22, (HGM4), 406-407, 1978a
LOC,CYG,LIN "Sparkes RS &: Exp Cell Res, 111, 492-495, 1978b
FUN,PEP,FOG "Spencer &: Nature, 204, 742-745, 1964
LOC,CYG,LIN "Wijnen LM &: Hum Genet, 37, 271-278, 1977

KEY

 carb, glyc

CLA

 coding, basic

LOC

 04 p14-q12

MIM

 MIM: 172000

EZN

 ENZYME: 5.4.2.2